Movement Disorders (revue)

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Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum.

Identifieur interne : 000259 ( Main/Exploration ); précédent : 000258; suivant : 000260

Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum.

Auteurs : I. Ruiz-Dediego [Espagne] ; J R Naranjo [Espagne] ; D. Hervé [Espagne] ; R. Moratalla [Espagne]

Source :

RBID : pubmed:25772224

Abstract

In rodents, the olfactory type G-protein α subunit (Gαolf) couples the dopamine D1 receptor (D1R) to adenylyl cyclase, triggering intracellular signaling and neuronal activation. In the striatum, Gαolf is enriched in the striosomes. Changes in Gαolf protein levels have been observed after dopamine depletion. However, the regulation of Gαolf expression by dopamine and dopamine receptors is not fully understood.

DOI: 10.1002/mds.26197
PubMed: 25772224


Affiliations:


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